Black Phosphorus Nanoparticles Potentiate the Anticancer Effect of Oxaliplatin in Ovarian Cancer Cell Line. (7th August 2017)

• Record Type: Journal Article
• Authors: Fojtů, Michaela; Chia, Xinyi; Sofer, Zdeněk; Masařík, Michal; Pumera, Martin
• Is Part Of: Advanced functional materials. Volume 27:Number 36(2017)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2017-08-07
• Subjects: black phosphorus -- drug delivery -- nanoparticles -- ovarian cancer -- oxaliplatin; Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adfm.201701955
• Languages: English
• ISSNs: 1616-301X

Abstract

Abstract : During the past few years, growing attention has been paid to black phosphorus (BP) and its unique optical, electrical, and catalytic properties. Furthermore, BP has proven to be biocompatible and biodegradable; qualities that present new opportunities for its utilization in the field of life sciences. However, despite all its suitable properties and applicability, its utilization in biomedicine is still in its infancy. This study reports on the synthesis of black phosphorus nanoparticles (BP NPs) and exploration of thier applicability in targeted drug delivery. BP NPs are loaded with platinum agents—cisplatin and oxaliplatin—and subjected to in vitro evaluation of targeted drug delivery. The BP NPs are not only able to load the investigated platinum derivatives on their surfaces, but also to transfer the therapeutic cargo to target specific tissue and to combine their effect with oxaliplatin, which leads to further potentiation of the anticancer effect. Abstract : Black phosphorus nanoparticles are surface‐loaded with platinum derivatives, investigated herein, to transfer a therapeutic cargo to a specific target tissue, to combine their effect with oxaliplatin, leading to further potentiation of the anticancer effect.