Beta adrenergic receptors in pigmented ciliary processes. Issue 12 (December 1982)

• Record Type: Journal Article
• Authors: Trope, G E; Clark, B
• Is Part Of: British journal of ophthalmology. Volume 66:Issue 12(1982)
• Page Start: 788
• Page End: 792
• Publication Date: 1982-12
• Subjects: Ophthalmology -- Periodicals; 617.7
• DOI: 10.1136/bjo.66.12.788
• Languages: English
• ISSNs: 0007-1161

Abstract

Abstract : Beta adrenergic receptors from membrane fragments of pigmented sheep eyes were studied and characterised by ligand binding techniques after the removal of melanin. In a representative experiment the beta max (total number of beta receptors) was 394.9 fmol/mg protein. The receptor affinity (Ka) was 440 pM. The potency series of drugs to displace 125I-HYP from the receptors was timolol = (-) propranolol greater than (+) propranolol greater than salbutamol greater than practolol. beta 1 Receptors were not detected in the ciliary processes. beta 2 Receptors were the prominent adrenergic receptors present. The theory as to how beta blockers work in glaucoma, their site of action, and the potential role of beta 2 blockers for use in intraocular pressure control is discussed.