A pilot study on the use of a perfluorohexyloctane/silicone oil solution as a heavier than water internal tamponade agent. Issue 6 (27th May 2005)

• Record Type: Journal Article
• Authors: Wong, D; Van Meurs, J C; Stappler, T; Groenewald, C; Pearce, I A; McGalliard, J N; Manousakis, E; Herbert, E N
• Is Part Of: British journal of ophthalmology. Volume 89:Issue 6(2005)
• Page Start: 662
• Page End: 665
• Publication Date: 2005-05-27
• Subjects: ERM, epiretinal membranes -- PFCL, perfluorocarbon liquids -- PPV, pars plana vitrectomy -- PVR, proliferative vitreoretinopathy -- RD, retinal detachments -- SiO, silicone oil; perfluorohexyloctane -- silicone oil -- proliferative vitreoretinopathy -- retinal detachment; Ophthalmology -- Periodicals; 617.7
• DOI: 10.1136/bjo.2004.055178
• Languages: English
• ISSNs: 0007-1161

Abstract

Abstract : Aims: To report a prospective two centred non-comparative interventional pilot study of a solution of perfluorohexyloctane and silicone oil (Densiron-68) as a heavier than water internal tamponade. Methods: 42 consecutive patients were recruited. The indications include proliferative vitreoretinopathy, retinal detachments arising from inferior retinal breaks, and inability to posture. Results: The success rate with one operation using Densiron was 81% and with further surgery 93%. At the end of the study all tamponade agents were removed in 90% of patients. Visual acuity improved from mean logMAR of 1.41 (SD 0.64) to 0.94 (SD 0.57), p = 0.001. There was little evidence of dispersion and excessive inflammation. Conclusion: This new tamponade agent is being compared to conventional silicone oil in a prospective international randomised trial.