Reduced fluence versus standard photodynamic therapy in combination with intravitreal triamcinolone: short-term results of a randomised study. Issue 10 (27th June 2008)

• Record Type: Journal Article
• Authors: Sacu, S; Varga, A; Michels, S; Weigert, G; Polak, K; Vécsei-Marlovits, P V; Schmidt-Erfurth, U
• Is Part Of: British journal of ophthalmology. Volume 92:Issue 10(2008)
• Page Start: 1347
• Page End: 1351
• Publication Date: 2008-06-27
• Subjects: Ophthalmology -- Periodicals; 617.7
• DOI: 10.1136/bjo.2008.137885
• Languages: English
• ISSNs: 0007-1161

Abstract

Abstract : Background: To compare early treatment effect of reduced fluence versus standard photodynamic therapy (rPDT, sPDT, respectively) in combination with intravitreal triamcinolone (IVTA) in neovascular age-related macular degeneration. Methods: Forty patients received either sPDT (group A, n = 20) or rPDT (group B, n = 20) each followed by same-day 4 mg IVTA. Patients were examined at baseline, day 1, week 1, 4 and 12. Main outcomes were visual acuity, central retinal thickness (CRT), choroidal perfusion and macular sensitivity (MS). Results: Baseline characteristics were well balanced in both groups (p>0.05). At week 12, patients in group A had a mean loss of −3.7 letters compared with a gain of 3.4 letters in group B (p = 0.04, between both groups). Both treatment groups showed a similar course regarding CRT as well as MS (p>0.05). In 70% (14/20) of group A and 15% (3/20) of group B, a choroidal hypoperfusion in the area of treatment was observed after treatment (p<0.001). In 70% of group A and 55% of group B, a repeat treatment was indicated at week 12 (p = 0.55). Conclusions: At month 3, the rPDT+IVTA group showed a significantly better visual outcome, less alteration of the choroid and a trend for lower recurrence rate than the sPDT+IVTA group. Further follow-up of this study will provide information on long-term functional results and treatment durability.