Computational nanomedicine: modeling of nanoparticle-mediated hyperthermal cancer therapy. (August 2013)

• Record Type: Journal Article
• Authors: Kaddi, Chanchala D; Phan, John H; Wang, May D
• Is Part Of: Nanomedicine. Volume 8:Number 8(2013)
• Page Start: 1323
• Page End: 1333
• Publication Date: 2013-08
• Subjects: bioinformatics -- drug delivery -- hyperthermia -- mathematical modeling -- nanomedicine -- nanoparticle -- pharmacokinetics -- simulation; Nanotechnology -- Periodicals; Medical technology -- Periodicals; Nanotechnology -- Therapeutic use -- Periodicals; 610.28
• DOI: 10.2217/nnm.13.117
• Languages: English
• ISSNs: 1743-5889

Abstract

Nanoparticle-mediated hyperthermia for cancer therapy is a growing area of cancer nanomedicine because of the potential for localized and targeted destruction of cancer cells. Localized hyperthermal effects are dependent on many factors, including nanoparticle size and shape, excitation wavelength and power, and tissue properties. Computational modeling is an important tool for investigating and optimizing these parameters. In this review, we focus on computational modeling of magnetic and gold nanoparticle-mediated hyperthermia, followed by a discussion of new opportunities and challenges.