Colon mucosa of patients both with spondyloarthritis and Crohn's disease is enriched with macrophages expressing the scavenger receptor CD163. Issue 2 (27th May 2004)

• Record Type: Journal Article
• Authors: Demetter, P; De Vos, M; Van Huysse, J A; Baeten, D; Ferdinande, L; Peeters, H; Mielants, H; Veys, E M; De Keyser, F; Cuvelier, C A
• Is Part Of: Annals of the rheumatic diseases. Volume 64:Issue 2(2005)
• Page Start: 321
• Page End: 324
• Publication Date: 2004-05-27
• Subjects: IBD, inflammatory bowel disease -- SRCR, scavenger receptor cysteine-rich -- SpA, spondyloarthritis -- TNFα, tumour necrosis factor α; spondyloarthritis -- inflammatory bowel disease -- macrophages -- scavenger receptors; Rheumatism -- Periodicals; 616.723005
• DOI: 10.1136/ard.2003.018382
• Languages: English
• ISSNs: 0003-4967

Abstract

Abstract : Background: Crohn's disease is associated with an increased number of macrophages in ileal and colonic mucosa. Data on macrophages in gut mucosa of patients with spondyloarthritis (SpA) are scarce. Objective: To investigate macrophages and other antigen presenting cells in gut mucosa from patients with SpA and Crohn's disease, given the relationship between both entities. Methods: Biopsy specimens from patients with SpA, Crohn's disease, ulcerative colitis, and from controls were immunohistochemically stained with different markers for macrophages and dendritic cells. Slides were scored semiquantitatively on a four point scale. Results: SpA and Crohn's disease were associated with large numbers of CD68 + macrophages. Colon mucosa of both patients with SpA and Crohn's disease, but not ulcerative colitis, showed increased numbers of macrophages expressing the scavenger receptor CD163. Conclusions: Macrophages expressing the scavenger receptor CD163 are increased in colonic mucosa in SpA and in Crohn's disease, highlighting the relationship between these entities. The increased number of CD163 + macrophages in colon mucosa of patients with SpA suggests this is another argument for a role of macrophage scavenger receptors in this group of diseases.