Cushing's sign and severe traumatic brain injury in children after blunt trauma: a nationwide retrospective cohort study in Japan. Issue 3 (3rd March 2018)

• Record Type: Journal Article
• Authors: Yumoto, Tetsuya; Naito, Hiromichi; Yorifuji, Takashi; Maeyama, Hiroki; Kosaki, Yoshinori; Yamamoto, Hirotsugu; Tsukahara, Kohei; Osako, Takaaki; Nakao, Atsunori
• Is Part Of: BMJ open. Volume 8:Issue 3(2018)
• Publication Date: 2018-03-03
• Subjects: paediatric neurology -- paediatric neurosurgery; Medicine -- Research -- Periodicals; 610.72
• DOI: 10.1136/bmjopen-2017-020781
• Languages: English
• ISSNs: 2044-6055

Abstract

Abstract : Objective: We tested whether Cushing's sign could predict severe traumatic brain injury (TBI) requiring immediate neurosurgical intervention (BI-NSI) in children after blunt trauma. Design: Retrospective cohort study using Japan Trauma Data Bank. Setting: Emergency and critical care centres in secondary and tertiary hospitals in Japan. Participants: Children between the ages of 2 and 15 years with Glasgow Coma Scale motor scores of 5 or less at presentation after blunt trauma from 2004 to 2015 were included. A total of 1480 paediatric patients were analysed. Primary outcome measures: Patients requiring neurosurgical intervention within 24 hours of hospital arrival and patients who died due to isolated severe TBI were defined as BI-NSI. The combination of systolic blood pressure (SBP) and heart rate (HR) on arrival, which were respectively divided into tertiles, and its correlation with BI-NSI were investigated using a multiple logistic regression model. Results: In the study cohort, 297 (20.1%) exhibited BI-NSI. After adjusting for sex, age category and with or without haemorrhage shock, groups with higher SBP and lower HR (SBP ≥135 mm Hg; HR ≤92 bpm) were significantly associated with BI-NSI (OR 2.84, 95% CI 1.68 to 4.80, P<0.001) compared with the patients with normal vital signs. In age-specific analysis, hypertension and bradycardia were significantly associated with BI-NSI in a group of 7–10 and 11–15 years of age; however, no significant association was observed in a group of 2–6 years of age. Conclusions: Cushing's sign after blunt trauma was significantly associated with BI-NSI in school-age children and young adolescents.