A case study evaluating the portability of an executable computable phenotype algorithm across multiple institutions and electronic health record environments. (16th August 2018)

• Record Type: Journal Article
• Authors: Pacheco, Jennifer A; Rasmussen, Luke V; Kiefer, Richard C; Campion, Thomas R; Speltz, Peter; Carroll, Robert J; Stallings, Sarah C; Mo, Huan; Ahuja, Monika; Jiang, Guoqian; LaRose, Eric R; Peissig, Peggy L; Shang, Ning; Benoit, Barbara; Gainer, Vivian S; Borthwick, Kenneth; Jackson, Kathryn L; Sharma, Ambrish; Wu, Andy Yizhou; Kho, Abel N; Roden, Dan M; Pathak, Jyotishman; Denny, Joshua C; Thompson, William K
• Is Part Of: Journal of the American Medical Informatics Association. Volume 25:Number 11(2018)
• Page Start: 1540
• Page End: 1546
• Publication Date: 2018-08-16
• Subjects: phenotype -- electronic health records -- algorithms -- architecture -- genomics -- prostatic hyperplasia; Medical informatics -- Periodicals; Information Services -- Periodicals; Medical Informatics -- Periodicals; Médecine -- Informatique -- Périodiques; Informatica; Geneeskunde; Informatique médicale; Computer network resources; Electronic journals; 610.285
• DOI: 10.1093/jamia/ocy101
• Languages: English
• ISSNs: 1067-5027

Abstract

Abstract: Electronic health record (EHR) algorithms for defining patient cohorts are commonly shared as free-text descriptions that require human intervention both to interpret and implement. We developed the Phenotype Execution and Modeling Architecture (PhEMA, http://projectphema.org ) to author and execute standardized computable phenotype algorithms. With PhEMA, we converted an algorithm for benign prostatic hyperplasia, developed for the electronic Medical Records and Genomics network (eMERGE), into a standards-based computable format. Eight sites (7 within eMERGE) received the computable algorithm, and 6 successfully executed it against local data warehouses and/or i2b2 instances. Blinded random chart review of cases selected by the computable algorithm shows PPV ≥90%, and 3 out of 5 sites had >90% overlap of selected cases when comparing the computable algorithm to their original eMERGE implementation. This case study demonstrates potential use of PhEMA computable representations to automate phenotyping across different EHR systems, but also highlights some ongoing challenges.