Vitamin D metabolites in synovial fluid. Issue 5 (May 1987)

• Record Type: Journal Article
• Authors: Fairney, A; Straffen, A M; May, C; Seifert, M H
• Is Part Of: Annals of the rheumatic diseases. Volume 46:Issue 5(1987)
• Page Start: 370
• Page End: 374
• Publication Date: 1987-05
• Subjects: Rheumatism -- Periodicals; 616.723005
• DOI: 10.1136/ard.46.5.370
• Languages: English
• ISSNs: 0003-4967

Abstract

Abstract : This study has shown that it is possible to measure vitamin D metabolites and vitamin D binding protein (DBP) in synovial fluid as well as serum. Significant amounts of 25-OHD, 24, 25-(OH)2D, and DBP are present in synovial fluid. The 25-OHD and DBP maintain a serum:synovial fluid ratio of approximately 2:1 irrespective of the type of joint disease, whereas no such relationship was detected for 24, 25-(OH)2D. The possible reasons for these findings are diffusion of the metabolites into synovial fluid or local production from suitable precursors, or both.