Effect of pegaptanib sodium 0.3 mg intravitreal injections (Macugen) in intraocular pressure: posthoc analysis from V.I.S.I.O.N. study. Issue 11 (4th July 2014)

• Record Type: Journal Article
• Authors: Boyer, David S; Goldbaum, Mauro; Leys, Anita M; Starita, Carla
• Other Names: Blumenkranz M author non-byline.; Buyse M author non-byline.; Goldberg M author non-byline.; Gragoudas ES author non-byline.; Miller J author non-byline.; Schwartz SD author non-byline.; Singerman L author non-byline.; Yannuzzi L author non-byline.; Adamis AP author non-byline.; Guyer DR author non-byline.; O'Shaughnessy D author non-byline.; Buyse M author non-byline.; de Gronckel S author non-byline.; Fesneau G author non-byline.; Quinaux E author non-byline.; Tremolet D author non-byline.; Wang K author non-byline.; Brailey A author non-byline.; Finman J author non-byline.; Ting N author non-byline.; Bressler NM author non-byline.; Bressler SB author non-byline.; Denblow R author non-byline.; Schein OD author non-byline.; Seabrook S author non-byline.; Solomon S author non-byline.; Schachat AP author non-byline.; Philips D author non-byline.; Altaweel M author non-byline.; Davis MD author non-byline.; Blodi BA author non-byline.; Danis RP author non-byline.; Ip MS author non-byline.; 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da Silva R author non-byline.; Ruiz Moreno JM author non-byline.; Mones J author non-byline.; Figueroa M author non-byline.; Pournaras C author non-byline.; Zografos L author non-byline.; Lois N author non-byline.; Chakravarthy U author non-byline.; Hykin P author non-byline.; Chisholm I author non-byline.; Johnson MW author non-byline.; Marcus DM author non-byline.; Mandava N author non-byline.; Haller JA author non-byline.; Cangemi F author non-byline.; Boyer D author non-byline.; Kim I author non-byline.; Loewenstein J author non-byline.; Heier J author non-byline.; Reichel E author non-byline.; Falcone PM author non-byline.; Weissgold DJ author non-byline.; Conway BP author non-byline.; Garfinkel R author non-byline.; Glaser B author non-byline.; Lyon AT author non-byline.; Lewis H author non-byline.; Wells JA author non-byline.; Wilcox L author non-byline.; Fish G author non-byline.; Eliott D author non-byline.; Fekrat S author non-byline.; Taney B author non-byline.; Eaton AM author non-byline.; Deramo V author non-byline.; Wroblewski J author non-byline.; Tom D author non-byline.; Chow DR author non-byline.; Orth DH author non-byline.; Packo KH author non-byline.; Holz E author non-byline.; Mieler W author non-byline.; Kuppermann B author non-byline.; Sabates N author non-byline.; Cummings H author non-byline.; Pendergast SD author non-byline.; Gonzales C author non-byline.; Lim JI author non-byline.; Charles S author non-byline.; Sanislo S author non-byline.; Rosenfeld P author non-byline.; Connor T author non-byline.; Cantrill H author non-byline.; Willson R author non-byline.; Bailey-Freund K author non-byline.; Rosen R author non-byline.; Leonard R author non-byline.; Brucker A author non-byline.; Ho A author non-byline.; Sneed S author non-byline.; Friberg T author non-byline.; Klein M author non-byline.; Tornambe P author non-byline.; Stoller G author non-byline.; Capone A author non-byline.; Bernstein PS author non-byline.; McDonald HR author non-byline.; Schatz H author non-byline.; Johnson RN author non-byline.; Nanda M author non-byline.; Avery R author non-byline.; Wong K author non-byline.; Grizzard WS author non-byline.; Higgins P author non-byline.; Hudson H author non-byline.; Joffe L author non-byline.; Varenhorst M author non-byline.; Slusher MM author non-byline.; Adamis AP author non-byline.; Betts F author non-byline.; Cunningham E author non-byline.; Curtiss K author non-byline.; Guyer DR author non-byline.; Harrison E author non-byline.; Katz B author non-byline.; Masonson HN author non-byline.; DeMarco R author non-byline.; O'Shaughnessy D author non-byline.; Beals C author non-byline.; Patel M author non-byline.; Rodriguez I author non-byline.; Starita C author non-byline.;
• Is Part Of: British journal of ophthalmology. Volume 98:Issue 11(2014)
• Page Start: 1543
• Page End: 1546
• Publication Date: 2014-07-04
• Subjects: Intraocular Pressure -- Neovascularisation -- Treatment Medical -- Vision; Ophthalmology -- Periodicals; 617.7
• DOI: 10.1136/bjophthalmol-2013-304075
• Languages: English
• ISSNs: 0007-1161

Abstract

Abstract : Objective: To assess the rate of pegaptanib-associated sustained intraocular pressure (IOP) elevation. Methods: A posthoc analysis was conducted on all IOP measurements, except the immediate 30-min postinjection, from all subjects randomised to pegaptanib 0.3 mg or sham injections continuously in the first 2 years of the Vascular endothelial growth factor Inhibition Study in Ocular Neovascularisation (V.I.S.I.O.N.) study. Measurements were taken with Goldmann applanation tonometer or Tonopen, except at baseline and in cases of an IOP reading >30 mm Hg when a Goldmann applanation tonometer was mandatory. Results: Of 221 subjects, IOP measurements ≥22 mm Hg were seen in 28/114 and 23/107 subjects of the pegaptanib and sham subgroups, respectively (p=0.6338) and measurements ≥24 mm Hg were observed in eight and eight subjects in the pegaptanib and sham groups, respectively. More than two measurements ≥22 mm Hg occurred in six and 10 subjects (p=0.3025), and more than two measurements ≥24 mm Hg were observed in one and four subjects in the pegaptanib and sham groups, respectively. One patient with sustained IOP elevation in the pegaptanib study group, and four in the sham group, had IOP lowering medication added during the course of the study. No subject required glaucoma surgery. Conclusions: In V.I.S.I.O.N., after 2 years, there was no evidence of sustained IOP elevation associated with pegaptanib 0.3 mg use. Trial registration number: NCT00321997.