Longitudinal changes in anterior chamber depth and axial length in Asian subjects after trabeculectomy surgery. Issue 7 (17th May 2013)

• Record Type: Journal Article
• Authors: Husain, Rahat; Li, Wen; Gazzard, Gus; Foster, Paul J; Chew, Paul T; Oen, Francis T; Phillips, Rachel; Khaw, Peng T; Seah, Steve K; Aung, Tin
• Is Part Of: British journal of ophthalmology. Volume 97:Issue 7(2013)
• Page Start: 852
• Page End: 856
• Publication Date: 2013-05-17
• Subjects: Glaucoma -- Treatment Surgery -- Anterior chamber; Ophthalmology -- Periodicals; 617.7
• DOI: 10.1136/bjophthalmol-2012-302442
• Languages: English
• ISSNs: 0007-1161

Abstract

Abstract : Background/aims: To investigate longitudinal changes in anterior chamber depth (ACD) and axial length (AXL) over 5 years after trabeculectomy surgery in Asian patients with primary glaucoma, and to identify factors associated with these changes. Methods: In this prospective cohort study, phakic subjects with primary glaucoma who underwent trabeculectomy had ACD and AXL measured over 5 years. The effect of intraocular pressure (IOP) on ACD and AXL was determined. Subjects were divided into two groups (high or low fluctuation of ACD/AXL) and factors were compared to determine if there were factors associated with greater fluctuation. Results: 122 subjects were analysed. The majority of subjects were male (75.4%) and Chinese (77%). ACD and AXL were shallower/shorter compared with baseline at all postoperative visits, with a mean decrease of 0.11 mm (95% CI 0.07 to 0.15 mm, p<0.01) and 0.16 mm (95%CI 0.11 to 0.20 mm, p<0.01), respectively. Patients with primary open angle glaucoma (POAG) had higher odds of fluctuations in longitudinal measurements of ACD (OR=8.74, p<0.01) and AXL (OR=5.60, p<0.01) compared with patients with primary angle closure glaucoma. For every 1 mm Hg decrease in IOP, ACD and AXL decreased by 0.02 mm (p<0.01) and 0.01 mm (p=0.03), respectively, for POAG patients with emmetropia or mild myopia. Conclusions: Trabeculectomy resulted in a decrease in both ACD and AXL, and these changes were persistent over a period of 5 years.