Ionization sources and mass analyzers in MS imaging. (October 2015)

• Record Type: Journal Article
• Authors: Tsai, Yu-Hsuan; Menger, Robert F; Drexler, Dieter M; Yost, Richard A; Garrett, Timothy J
• Is Part Of: Bioanalysis. Volume 7:Number 20(2015)
• Page Start: 2629
• Page End: 2637
• Publication Date: 2015-10
• Subjects: Drugs -- Analysis -- Periodicals; 615.19005
• DOI: 10.4155/bio.15.187
• Languages: English
• ISSNs: 1757-6180

Abstract

Drug absorption, distribution, metabolism, excretion and toxicology study is one important step in drug discovery and development. MS imaging has become one of the popular methods in this field. Here, selected ionization methods such as matrix-assisted laser desorption/ionization, secondary ion MS and desorption electrospray ionization have been briefly discussed. To differentiate drug and drug metabolites from endogenous compounds present in the biological system, exact mass and/or tandem MS is necessary. As a result, mass analyzers such as time-of-flight, Fourier transform ion cyclotron resonance or Orbitrap are often the method of choice and are briefly introduced.