Chitosan coatings to control release and target tissues for therapeutic delivery. (July 2015)

• Record Type: Journal Article
• Authors: Jennings, Jessica Amber; Wells, Carlos Montez; McGraw, Gregory S; Velasquez Pulgarin, Diego A; Whitaker, Marsalas D; Pruitt, Reginald L; Bumgardner, Joel David
• Is Part Of: Therapeutic delivery. Volume 6:Number 7(2015)
• Page Start: 855
• Page End: 871
• Publication Date: 2015-07
• Subjects: Drug delivery systems -- Periodicals; Therapeutics -- Periodicals; 615.6
• DOI: 10.4155/tde.15.31
• Languages: English
• ISSNs: 2041-5990

Abstract

The natural biopolymer chitosan has versatile applications in therapeutic delivery. Coating drug delivery matrices or biomaterials with chitosan offers several advantages in drug delivery, including control of drug release, slowing degradation rate and improving biocompatibility. Advanced uses of chitosan in coating form include targeting drug delivery vehicles to specific tissue as well as providing a stimulus-controlled release response. The present review summarizes the current applications of chitosan coatings in the context of different biomaterial delivery technologies, as well as future directions of chitosan coatings for drug delivery technologies under development.