Combining hard and soft magnetism into a single core-shell nanoparticle to achieve both hyperthermia and image contrast. (October 2015)

• Record Type: Journal Article
• Authors: Yang, Qiuhong; Gong, Maogang; Cai, Shuang; Zhang, Ti; Douglas, Justin T; Chikan, Viktor; Davies, Neal M; Lee, Phil; Choi, In-Young; Ren, Shenqiang; Forrest, M Laird
• Is Part Of: Therapeutic delivery. Volume 6:Number 10(2015)
• Page Start: 1195
• Page End: 1210
• Publication Date: 2015-10
• Subjects: Drug delivery systems -- Periodicals; Therapeutics -- Periodicals; 615.6
• DOI: 10.4155/tde.15.68
• Languages: English
• ISSNs: 2041-5990

Abstract

Background: A biocompatible core/shell structured magnetic nanoparticles (MNPs) was developed to mediate simultaneous cancer therapy and imaging.Methods & results: A 22-nm MNP was first synthesized via magnetically coupling hard (FePt) and soft (Fe3 O4 ) materials to produce high relative energy transfer. Colloidal stability of the FePt@Fe3 O4 MNPs was achieved through surface modification with silane-polyethylene glycol (PEG). Intravenous administration of PEG-MNPs into tumor-bearing mice resulted in a sustained particle accumulation in the tumor region, and the tumor burden of treated mice was a third that of the mice in control groups 2 weeks after a local hyperthermia treatment. In vivo magnetic resonance imaging exhibited enhanced T2 contrast in the tumor region.Conclusion: This work has demonstrated the feasibility of cancer theranostics with PEG-MNPs.