Photocontrolled Release of the Anticancer Drug Chlorambucil with Caged Harmonic Nanoparticles. Issue 1 (7th January 2020)

• Record Type: Journal Article
• Authors: Vuilleumier, Jérémy; Gaulier, Geoffrey; De Matos, Raphaël; Mugnier, Yannick; Campargue, Gabriel; Wolf, Jean‐Pierre; Bonacina, Luigi; Gerber‐Lemaire, Sandrine
• Is Part Of: Helvetica chimica acta. Volume 103:Issue 1(2020)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-01-07
• Subjects: chlorambucil -- nanoparticles -- NIR-light triggered delivery -- photosensitive tether -- second harmonic emission; Chemistry -- Periodicals; Chemistry, Analytical -- periodicals; Chimie -- Périodiques; 540
• DOI: 10.1002/hlca.201900251
• Languages: English
• ISSNs: 0018-019X

Abstract

Abstract: While chemotherapy is one of the most used treatments in oncology, the systemic administration of chemotherapeutics generally results in undesired damages to healthy tissues and cells, side effects such as severe nausea and leukopenia, and reduced efficacy due to multidrug resistance and poor target accessibility. The limitations of conventional chemotherapy formulation have prompted the development of alternative nanomaterials‐based strategies to achieve targeted and stimuli sensitive payload delivery to reach optimal local drug concentration at tumor sites. In this study, the anticancer drug chlorambucil (Clb) was conjugated to the surface of silica coated lithium niobate (LNO) harmonic nanoparticles (HNPs) using a photocaging tether based on coumarin‐4‐yl methyl derivative. Upon laser pulsed femtosecond irradiation at 790 nm, the second harmonic emission from the metal oxide core induced the efficient release of Clb, with concomitant contribution from the nonlinear absorption of the coumarin (CM)‐based moiety. Abstract :