A Neutrophil‐Inspired Supramolecular Nanogel for Magnetocaloric–Enzymatic Tandem Therapy. (21st January 2020)

• Record Type: Journal Article
• Authors: Zhang, Qi; Wu, Jiaojiao; Wang, Jingjing; Wang, Xia; Wu, Chu; Chen, Mengwei; Wu, Qing; Lesniak, Maciej S.; Mi, Yongli; Cheng, Yu; Wang, Qigang
• Is Part Of: Angewandte Chemie. Volume 132:Number 9(2020)
• Page Start: 3761
• Page End: 3767
• Publication Date: 2020-01-21
• Subjects: Bio-Oxidation -- Krebstherapie -- Nanogele -- Reaktive Sauerstoffspezies -- Selbstassemblierung; Chemistry -- Periodicals; 540
• DOI: 10.1002/ange.201915118
• Languages: English
• ISSNs: 0044-8249

Abstract

Abstract: Neutrophils can responsively release reactive oxygen species (ROS) to actively combat infections by exogenous stimulus and cascade enzyme catalyzed bio‐oxidation. A supramolecular nanogel is now used as an artificial neutrophil by enzymatic interfacial self‐assembly of peptides (Fmoc‐Tyr(H2 PO3 )‐OH) with magnetic nanoparticles (MNPs) and electrostatic loading of chloroperoxidase (CPO). The MNPs within the nanogel can elevate H2 O2 levels in cancer cells under programmed alternating magnetic field (AMF) similar to the neutrophil activator, and the loaded CPO within protective peptides nanolayer converts the H2 O2 into singlet oxygen ( 1 O2 ) in a sustained manner for neutrophil‐inspired tumor therapy. As a proof of concept study, both the H2 O2 and 1 O2 in cancer cells increase stepwise under a programmed alternating magnetic field. An active enzyme dynamic therapy by magnetically stimulated oxygen stress and sustained enzyme bio‐oxidation is thus shown with studies on both cells and animals. Abstract : Auf hohem ROS : Nanogele werden als aktivierbare und programmiert regulierbare Neutrophil‐Imitatoren für magnetokalorisch‐enzymatische Tandemtherapie von Krebs eingesetzt. Das Nanogel zeigt ausgezeichnete Stabilität und Biosicherheit. Magnetische Aktivierung und programmierte Hochregulierung von reaktiven Sauerstoffspezies (ROS) in Krebszellen wird erreicht, was eine erfolgreiche, durch Singulett‐Sauerstoff vermittelte Tumorzellen‐Ausbreitungshemmung demonstriert.