HLA associations in sarcoidosis: a study of two ethnic groups. Issue 1 (January 1984)

• Record Type: Journal Article
• Authors: Gardner, J; Kennedy, H G; Hamblin, A; Jones, E
• Is Part Of: Thorax. Volume 39:Issue 1(1984)
• Page Start: 19
• Page End: 22
• Publication Date: 1984-01
• Subjects: Chest -- Diseases -- Periodicals; Thorax; Chest -- Diseases; Periodicals; Periodicals; 617.54
• DOI: 10.1136/thx.39.1.19
• Languages: English
• ISSNs: 0040-6376

Abstract

Abstract : We report results of HLA-A, B, C, and DR typing in groups of white Caucasians of English descent and black West Indians of African descent with sarcoidosis. In the English patients we found a significantly increased frequency of Cw7, which was not found in the West Indian patients. Our results also suggest that DR3 and, in particular, inheritance of the B8/Cw7/DR3 haplotype is associated with good prognosis in English patients with sarcoidosis. There was no association between any HLA antigen and prognosis in the West Indian patients in this study.