OPRM1 rs1799971 polymorphism and opioid dependence: evidence from a meta-analysis. (May 2013)

• Record Type: Journal Article
• Authors: Haerian, Batoul Sadat; Haerian, Monir Sadat
• Is Part Of: Pharmacogenomics. Volume 14:Number 7(2013)
• Page Start: 813
• Page End: 824
• Publication Date: 2013-05
• Subjects: heroin -- meta-analysis -- opioid dependence -- polymorphism; Pharmacogenomics -- Periodicals; 615.1
• DOI: 10.2217/pgs.13.57
• Languages: English
• ISSNs: 1462-2416

Abstract

The OPRM1 gene encodes the µ-opioid receptor, which is the primary site of action of most opioids. Several studies and three meta-analyses have examined a possible link between the exonic OPRM1 A118G (rs1799971) polymorphism and opioid dependence; however, results have been inconclusive. Therefore, a systematic review and meta-analysis have been carried out to examine whether this polymorphism is associated with opioid dependence. Thirteen studies (n = 9385), comprising 4601 opioid dependents and 4784 controls, which evaluated association of the OPRM1 rs1799971 polymorphism with susceptibility to opioids, were included in this study. Our meta-analysis showed significant association between this polymorphism and susceptibility to opioid dependence in overall studies under a codominant model, as well as susceptibility to opioid dependence or heroin dependence in Asians under an autosomal dominant model. The nonsynonymous OPRM1 rs1799971 might be a risk factor for addiction to opioids or heroin in an Asian population.