A TRAV26‐1‐encoded recognition motif focuses the biased T cell response in celiac disease. Issue 1 (30th October 2019)

• Record Type: Journal Article
• Authors: Frick, Rahel; Gunnarsen, Kristin Støen; Dahal‐Koirala, Shiva; Risnes, Louise Fremgaard; Sollid, Ludvig M.; Sandlie, Inger; Høydahl, Lene Støkken; Løset, Geir Åge
• Is Part Of: European journal of immunology. Volume 50:Issue 1(2020)
• Page Start: 142
• Page End: 145
• Publication Date: 2019-10-30
• Subjects: Celiac disease -- pMHC recognition -- Repertoire bias -- TCR -- TRAV26‐1; Immunology -- Periodicals; 616.079
• DOI: 10.1002/eji.201948235
• Languages: English
• ISSNs: 0014-2980

Abstract

Abstract : The semi‐public T‐cell response towards the gluten epitope DQ2.5‐glia‐α2 uses a prototypic TCR encoded by the germline segments TRAV26‐1 and TRBV7‐2 . Through mutagenesis experiments, we show that a TRAV26‐1 encoded recognition motif contacts the MHC β‐chain and the TCR CDR3β loop underpinning this conserved T‐cell response restricted to the prototypic TCRs.