Effect of budesonide on pulmonary hyperinflation in young asthmatic children. Issue 11 (November 1988)

• Record Type: Journal Article
• Authors: Greenough, A; Pool, J; Gleeson, J G; Price, J F
• Is Part Of: Thorax. Volume 43:Issue 11(1988)
• Page Start: 937
• Page End: 938
• Publication Date: 1988-11
• Subjects: Chest -- Diseases -- Periodicals; Thorax; Chest -- Diseases; Periodicals; Periodicals; 617.54
• DOI: 10.1136/thx.43.11.937
• Languages: English
• ISSNs: 0040-6376

Abstract

Abstract : In 19 asthmatic children, aged 2-6 years, the effect of six weeks' treatment with inhaled budesonide or placebo on functional residual capacity (FRC--helium dilution) and bronchodilator responsiveness was assessed in a double blind, randomised crossover trial. FRC was increased in most children at the start of treatment. Treatment with budesonide was associated with a reduction in FRC by comparison with placebo (median change 9% v 0%; p less than 0.05). There was a trend towards a greater response to a bronchodilator after budesonide. The results suggest that inhaled corticosteroids reduce hyperinflation in young asthmatic children.