Activation of Prodrugs by NIR‐Triggered Release of Exogenous Enzymes for Locoregional Chemo‐photothermal Therapy. (30th April 2019)

• Record Type: Journal Article
• Authors: Cheng, Li; Zhang, Fengrong; Wang, Shunhao; Pan, Xueting; Han, Sichong; Liu, Shuang; Ma, Junjie; Wang, Hongyu; Shen, Heyun; Liu, Huiyu; Yuan, Qipeng
• Is Part Of: Angewandte Chemie. Volume 131:Number 23(2019)
• Page Start: 7810
• Page End: 7814
• Publication Date: 2019-04-30
• Subjects: Chemo-photothermale Therapie -- Exogene Enzyme -- Kontrollierte Wirkstoffabgabe -- Nah-IR-Licht -- Prodrugs; Chemistry -- Periodicals; 540
• DOI: 10.1002/ange.201902476
• Languages: English
• ISSNs: 0044-8249

Abstract

Abstract: Enzymes have been used to direct the conversion of prodrugs in cancer therapy. However, non‐specific distribution of endogenous enzymes seriously hinders their bioapplications. Herein, we developed a near‐infrared‐triggered locoregional chemo‐photothermal therapy based on the exogenous enzyme delivery and remolded tumor mivroenvironment. The catalytic efficiency of enzymes was enhanced by the hyperthermia, and the therapeutic efficacy of photothermal therapy (PTT) was improved owing to the inhibition of heat shock protein 90 by chemotherapeutics. The locoregional chemo‐phototherapy achieved a one‐time successful cure in 4T1 tumor‐bearing mice model. Thus, a mutually reinforcing feedback loop between PTT and chemotherapy can be initiated by the irradiation, which holds a promising future in cancer therapy. Abstract : Exogene Marosinase wurde in photoresponsive wabenartige Gold‐Nanopartikel eingekapselt, um die Enzymaktivität zu maskieren und Tumorgewebe anzusteuern. Nah‐IR‐Licht löst die Abgabe der Myrosinase aus, die die Umwandlung von ungiftigem Glucoraphenin in therapeutisches Sulforaphen in Tumorgewebe katalysiert, was eine lokoregionale chemo‐photothermale Therapie ermöglicht.