Progression characteristics of ellipsoid zone loss in macular telangiectasia type 2. Issue 7 (9th April 2019)

• Record Type: Journal Article
• Authors: Pauleikhoff, Daniel; Bonelli, Roberto; Dubis, Adam M; Gunnemann, Frederic; Rothaus, Kai; Charbel Issa, Peter; Heeren, Tjebo FC; Peto, Tunde; Clemons, Traci E; Chew, Emily Y; Bird, Alan C; Sallo, Ferenc B
• Other Names: Bakri Sophie investigator.; Bernstein Paul S investigator.; Blodi Barbara investigator.; Brucker Alexander investigator.; Bucher Felicitas investigator.; Chung Mina investigator.; Comer Grant investigator.; Constable Ian investigator.; Cooney Michael investigator.; Do Diana investigator.; Duncan Jacque investigator.; Egan Catherine investigator.; Elman Michael J investigator.; Fawzi Amani investigator.; Friedlander Martin investigator.; Gaudric Alain investigator.; Gillies Mark C investigator.; Goldberg Roger investigator.; Googe Joseph M investigator.; Guymer Robyn investigator.; Higgins Patrick investigator.; Holz Frank investigator.; Houghton Odette investigator.; Hoyng Carel B investigator.; Hubschman Jean‐Pierre investigator.; Jhaveri Chirag investigator.; Khanani Arshad investigator.; Lally David investigator.; Lee Cecilia investigator.; Lee Michael investigator.; Miller Joan W investigator.; Miller Daniel investigator.; Moisseiev Joseph investigator.; Murphy Robert investigator.; Narayanan Raja investigator.; Randhawa Sandeep investigator.; Raphaelian Paul V investigator.; Rich Ryan investigator.; Rosen Richard investigator.; Rosenfeld Philip investigator.; Ruys Joke investigator.; Sahel Jose‐Alain investigator.; Schwartz Steven investigator.; Singerman Lawrence investigator.; Sneed Scott investigator.; Soubrane Gisele investigator.; Vingerling Johannes R investigator.; Warrow David investigator.; Weinberg David investigator.; Wolf Sebastian investigator.; Wykoff Charles investigator.; Yan Jiong investigator.; Yannuzzi Lawrence A investigator.; Zhuk Stanislav A investigator.;
• Is Part Of: Acta ophthalmologica. Volume 97:Issue 7(2019)
• Page Start: e998
• Page End: e1005
• Publication Date: 2019-04-09
• Subjects: ellipsoid zone -- en face image -- MacTel -- macular telangiectasia type 2 -- OCT; Ophthalmology -- Periodicals; 617.7005
• DOI: 10.1111/aos.14110
• Languages: English
• ISSNs: 1755-375X

Abstract

Abstract: Purpose: To investigate the progression characteristics of ellipsoid zone (EZ) loss in eyes with macular telangiectasia type 2 (MacTel) as reflected by area and linear measurements, and their relevance for visual acuity. Methods: Participants were selected from the MacTel Study cohort. Linear and area measurements of EZ loss were performed in Spectral‐Domain Optical Coherence Tomograph (SD‐OCT) volume scans. Progression characteristics and correlations between linear and area measurements were analysed using linear mixed effects models. Results: A total of 134 eyes of 70 patients were included (85 eyes with follow‐up, mean 4.7 years, range: 1.4–8 years). Ellipsoid zone (EZ) loss significantly progressed at a mean annual increment of 0.057 mm 2 (p = 0.005). The progression rate was non‐linear and interacted significantly with initial EZ lesion size indicating an exponential growth before reaching a plateau. There was a strong heterogeneity in area sizes between fellow eyes. EZ break length had a significant linear effect on EZ break area ( b = 1.06, p < 0.001) and could predict it. The location of the EZ break had a significant impact on visual acuity. Conclusion: Ellipsoid zone (EZ) loss in MacTel has a non‐linear progression characteristic, and its rate depends on area size at baseline, which must be taken into account at sample selection in clinical trials. Our results show a good correlation of linear and area measures of EZ loss and a segregation of best‐corrected visual acuity by EZ location, which may help routine clinical practice.