Association between acute respiratory disease events and the MUC5B promoter polymorphism in smokers. Issue 11 (13th February 2018)

• Record Type: Journal Article
• Authors: Ash, Samuel Y; Harmouche, Rola; Putman, Rachel K; Ross, James C; Martinez, Fernando J; Choi, Augustine M; Bowler, Russell P; Regan, Elizabeth A; Curtis, Jeffrey L; Han, MeiLan K; Boucher, Richard C; O'Neal, Wanda K; Hatabu, Hiroto; Lynch, David A; Rosas, Ivan O; Hunninghake, Gary M; San Jose Estepar, Raul; Washko, George R
• Is Part Of: Thorax. Volume 73:Issue 11(2018)
• Page Start: 1071
• Page End: 1074
• Publication Date: 2018-02-13
• Subjects: copd exacerbations -- interstitial fibrosis -- idiopathic pulmonary fibrosis; Chest -- Diseases -- Periodicals; Thorax; Chest -- Diseases; Periodicals; Periodicals; 617.54
• DOI: 10.1136/thoraxjnl-2017-211208
• Languages: English
• ISSNs: 0040-6376

Abstract

Abstract : A single-nucleotide polymorphism (rs35705950) in the mucin 5B ( MUC5B ) gene promoter is associated with pulmonary fibrosis and interstitial features on chest CT but may also have beneficial effects. In non-Hispanic whites in the COPDGene cohort with interstitial features (n=454), the MUC5B promoter polymorphism was associated with a 61% lower odds of a prospectively reported acute respiratory disease event (P=0.001), a longer time-to-first event (HR=0.57; P=0.006) and 40% fewer events (P=0.016). The MUC5B promoter polymorphism may have a beneficial effect on the risk of acute respiratory disease events in smokers with interstitial CT features.