Gold nanoparticles to improve HIV drug delivery. (July 2015)

• Record Type: Journal Article
• Authors: Garrido, Carolina; Simpson, Carrie A; Dahl, Noelle P; Bresee, Jamee; Whitehead, Daniel C; Lindsey, Erick A; Harris, Tyler L; Smith, Candice A; Carter, Carly J; Feldheim, Daniel L; Melander, Christian; Margolis, David M
• Is Part Of: Future medicinal chemistry. Volume 7:Number 9(2015)
• Page Start: 1097
• Page End: 1107
• Publication Date: 2015-07
• Subjects: Pharmaceutical chemistry -- Periodicals; 615.19005
• DOI: 10.4155/fmc.15.57
• Languages: English
• ISSNs: 1756-8919

Abstract

Background: Antiretroviral therapy (ART) has improved lifespan and quality of life of patients infected with the HIV-1. However, ART has several potential limitations, including the development of drug resistance and suboptimal penetration to selected anatomic compartments. Improving the delivery of antiretroviral molecules could overcome several of the limitations of current ART.Results & Conclusion: Two to ten nanometer diameter inorganic gold crystals serve as a base scaffold to combine molecules with an array of properties in its surface. We show entry into different cell types, antiviral activity of an HIV integrase inhibitor conjugated in a gold nanoparticle and penetration into the brain in vivo without toxicity. Herein, gold nanoparticles prove to be a promising tool to use in HIV therapy.