Modifying peptides to enhance permeability. (June 2015)
- Record Type:
- Journal Article
- Title:
- Modifying peptides to enhance permeability. (June 2015)
- Main Title:
- Modifying peptides to enhance permeability
- Authors:
- Vorherr, Thomas
- Abstract:
- Recently, peptides have been validated to address intracellular targets and/or to be orally bioavailable. This review describes some of these scaffolds, offers insight in new cyclization methodologies thought to be beneficial to enhance permeability, and highlights modification on peptides thought to improve oral bioavailability. In this context, side chains and back-bone derivatization beneficial to encourage cellular uptake are presented. In addition, new methodologies supporting the assessment of permeability are discussed.
- Is Part Of:
- Future medicinal chemistry. Volume 7:Number 8(2015)
- Journal:
- Future medicinal chemistry
- Issue:
- Volume 7:Number 8(2015)
- Issue Display:
- Volume 7, Issue 8 (2015)
- Year:
- 2015
- Volume:
- 7
- Issue:
- 8
- Issue Sort Value:
- 2015-0007-0008-0000
- Page Start:
- 1009
- Page End:
- 1021
- Publication Date:
- 2015-06
- Subjects:
- Pharmaceutical chemistry -- Periodicals
615.19005 - Journal URLs:
- http://www.future-science-group.com/m/102 ↗
http://www.future-science.com/ ↗ - DOI:
- 10.4155/fmc.15.43 ↗
- Languages:
- English
- ISSNs:
- 1756-8919
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - BLDSS-3PM
British Library HMNTS - ELD Digital store - Ingest File:
- 17669.xml