Utilizing diversity-oriented synthesis in antimicrobial drug discovery. (November 2014)

• Record Type: Journal Article
• Authors: Comer, Eamon; Duvall, Jeremy R; duPont Lee, Maurice
• Is Part Of: Future medicinal chemistry. Volume 6:Number 17(2014)
• Page Start: 1927
• Page End: 1942
• Publication Date: 2014-11
• Subjects: chemical complexity -- diversity-oriented synthesis -- drug discovery -- hepatitis C virus -- infectious disease -- malaria -- orthopoxviruses -- Trypanosoma cruzi; Pharmaceutical chemistry -- Periodicals; 615.19005
• DOI: 10.4155/fmc.14.111
• Languages: English
• ISSNs: 1756-8919

Abstract

The development of resistance to existing antimicrobials has created a threat to human health that is not being addressed through our current drug pipeline. Limitations with the use of commercial vendor libraries and natural products have created a need for new types of small molecules to be screened in antimicrobial assays. Diversity oriented synthesis (DOS) is a strategy for the efficient generation of compound collections with a high degree of structural diversity. Diversity-oriented synthesis molecules occupy the middle ground of both complexity and efficiency of synthesis between natural products and commercial libraries. In this review we focus upon the use of diversity-oriented synthesis compound collections for the discovery of new antimicrobial agents.