Kanuka honey versus aciclovir for the topical treatment of herpes simplex labialis: a randomised controlled trial. Issue 5 (14th May 2019)

• Record Type: Journal Article
• Authors: Semprini, Alex; Singer, Joseph; Braithwaite, Irene; Shortt, Nick; Thayabaran, Darmiga; McConnell, Melanie; Weatherall, Mark; Beasley, Richard
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Purdie Sally author non-byline.; Betty Sam author non-byline.; Appleford Sam author non-byline.; Fordham Samantha author non-byline.; Patel Samit author non-byline.; Preston Sara author non-byline.; Wallace Sarah author non-byline.; Ion Sascha author non-byline.; Salih Shahlaa Al author non-byline.; Sullivan Sharon author non-byline.; Rauf Shazeel author non-byline.; Montgomerie Sheryl author non-byline.; Narain Shilpa author non-byline.; Namjou Shirin author non-byline.; Zhang Shuji author non-byline.; Singh Simerjeet author non-byline.; Stanley Sjaani author non-byline.; Schwaum Sonia author non-byline.; Jo Steve author non-byline.; Zannat Sultana author non-byline.; Baker Tanya author non-byline.; Pornchaisuksiri Tyler author non-byline.; Sharma Utsav author non-byline.; Douglas Vicki author non-byline.; Rameke Victoria author non-byline.; Ho Vincent author non-byline.; Usher Vioky author non-byline.; Harley Violet author non-byline.; Gangapuri Vishwatej author non-byline.; Greene Warren author non-byline.; Parkes Wendy author non-byline.; Gia William author non-byline.; Gordon Wilma author non-byline.; Weng Yalun author non-byline.; Razoki Yasmin author non-byline.; Savage Yolanda author non-byline.; Li Zheng author non-byline.;
• Is Part Of: BMJ open. Volume 9:Issue 5(2019)
• Publication Date: 2019-05-14
• Subjects: herpes simplex labialis -- randomised controlled trial -- kanuka honey -- cold sore -- aciclovir -- pragmatic trial; Medicine -- Research -- Periodicals; 610.72
• DOI: 10.1136/bmjopen-2018-026201
• Languages: English
• ISSNs: 2044-6055

Abstract

Abstract : Objective: To compare New Zealand medical grade kanuka honey with topical aciclovir for the treatment of herpes simplex labialis. Design: Prospective parallel randomised controlled open-label superiority trial. Setting: 76 community pharmacies across New Zealand between 10 September 2015 and 13 December 2017. Participants: 952 adults randomised within the first 72 hours of a herpes simplex labialis episode. Interventions: Random assignment 1:1 to either 5% aciclovir cream or medical grade kanuka honey (90%)/glycerine (10%) cream, both applied five times daily. Outcome measures: The primary outcome was time from randomisation to return to normal skin (stage 7). Secondary outcomes included time from randomisation to stage 4 (open wound), time from stage 4 to 7, maximal pain, time to pain resolution and treatment acceptability. Results: Primary outcome variable: Kaplan-Meier-based estimates (95% CI) for the median time in days for return to normal skin were 8 (8 to 9) days for aciclovir and 9 (8 to 9) for honey; HR (95% CI) 1.06 (0.92 to 1.22), p=0.56. There were no statistically significant differences between treatments for all secondary outcome variables. No related serious adverse events were reported. Conclusion: There was no evidence of a difference in efficacy between topical medical grade kanuka honey and 5% aciclovir in the pharmacy-based treatment of herpes simplex labialis. Trial registration number: ACTRN12615000648527;Post-results