148 Longitudinal resting state changes in parkinson's disease. Issue 12 (14th November 2019)

• Record Type: Journal Article
• Authors: Naidu, Saadnah; Xing, Lily Yue; Mohammadi-Nejad, Ali-Reza; Sotiropoulos, Stamatios; Auer, Dorothee
• Is Part Of: Journal of neurology, neurosurgery and psychiatry. Volume 90:Issue 12(2019)
• Page Start: e41
• Page End: e41
• Publication Date: 2019-11-14
• Subjects: Neurology -- Periodicals; Nervous system -- Surgery -- Periodicals; Psychiatry -- Periodicals; 616.8
• DOI: 10.1136/jnnp-2019-ABN-2.138
• Languages: English
• ISSNs: 0022-3050

Abstract

Abstract : Introduction: There is currently no objective method of monitoring progression of Parkinson's disease (PD). We demonstrate resting-state magnetic resonance imaging (rs-MRI) as a potential biomarker of PD progression. Methods: 15 patients with idiopathic PD (age at baseline: mean±std, 66.43±7.16 years; follow-up: 69.46±7.09; Male, 10; H&Y baseline: 1.9±0.63; follow-up: 2.2±1.08) were recruited. Baseline and follow-up visits occurred 3.03± 0.18 years apart (Disease duration baseline: 3.61±1.33; follow-up: 6.64±1.38). (Disease severity: MDS-UPDRS-III baseline 27.17±15.28; follow-up: 35.53±16.45). Image acquisition: rs-MRI was performed using 3T GE 750 MRI; 32-channel head coil; TR=2000ms; TE=30ms; Eyes open, medicated. Analysis: An in-house optimised standardised pipeline was used based on FSL (1), MRIQC algorithm (2). Functional connectivity (FC) was derived from the following seeds (5 mm radius): primary motor cortex (M1), anterior and posterior putamen, caudate, supplementary motor area (SMA) and substantia nigra (SN). (Coordinates determined using AAL template and FSL atlas). Z score >2.3 used to report significance in a paired t test. Results: Overall, we found greater FC at baseline vs follow-up in the motor cortex and SN, while FC with the posterior putamen and SMA showed a dissociated pattern of increased and decreased FC changes with disease progression. Conclusion: Our preliminary analysis of a longitudinal dataset of >2 years mean duration show promising change patterns in line with progressive motor cortex and SN disconnection and complex putaminal and SMA disconnection.