T2-weighted combined with diffusion-weighted images for evaluating prostatic transition zone tumors at 3 Tesla. (April 2013)

• Record Type: Journal Article
• Authors: Ren, Jing; Yang, Yong; Zhang, Jinsong; Xu, Jian; Liu, Ying; Wei, Mengqi; Ge, Yali; Huan, Yi; Larson, Andrew C; Zhang, Zhuoli
• Is Part Of: Future oncology. Volume 9:Number 4(2013)
• Page Start: 585
• Page End: 593
• Publication Date: 2013-04
• Subjects: apparent diffusion coefficient -- diffusion-weighted imaging -- imaging biomarker -- MRI -- prostate cancer; Oncology -- Periodicals; 616.99405
• DOI: 10.2217/fon.13.14
• Languages: English
• ISSNs: 1479-6694

Abstract

Aim: We hypothesize that the combination of T2 -weighted (T2 W) MRI with diffusion-weighted imaging (DWI) methods provides a powerful clinical application for the differential diagnosis of prostate cancer and benign lesion in the prostatic transition zone (TZ).Methods: This retrospective study included 113 patients who were diagnosed with TZ lesions by MRI. The apparent diffusion coefficient values were compared between biopsy-proven benign and malignant lesions.Results: The apparent diffusion coefficient values for the malignant nodules were significantly lower than those of the benign nodules. The area under the curve values for T2 W imaging combined with DWI and T2 W imaging alone were 0.991 and 0.884, respectively.Conclusion: T2 W combined with DWI provides a powerful tool for noninvasive differentiation between malignant and benign prostatic hyperplasia nodules in the prostatic TZ.