Association study of TREM2 polymorphism rs75932628 with leucoaraiosis or Parkinson's disease in the Han Chinese population. Issue 1 (12th January 2016)

• Record Type: Journal Article
• Authors: Li, Zhiming; Zhong, Li; Gu, Long; Huang, Wenqing; Shi, Xinzhen; Zhang, Xilin; An, Xingkai; Lin, Qing; Tzeng, Chi-Meng
• Is Part Of: BMJ open. Volume 6:Issue 1(2016)
• Publication Date: 2016-01-12
• Subjects: Leukoaraiosis -- rs75932628-T -- p.R47H -- Han Chinese population; Medicine -- Research -- Periodicals; 610.72
• DOI: 10.1136/bmjopen-2015-009499
• Languages: English
• ISSNs: 2044-6055

Abstract

Abstract : Objectives: The previously reported functional mutation rs75932628-T (p.R47H) in the triggering receptor expressed on myeloid cells 2 (TREM2) is a genetic risk factor for Alzheimer's disease, Parkinson's disease (PD) and frontotemporal dementia, in European populations. This study aims to assess the genetic association of the variant rs75932628-T with PD and leucoaraiosis (LA) in a Han Chinese population. Setting: This population-based study was conducted in China by Xiamen University and its affiliated hospital. Participants: 308 patients with LA, 342 patients with PD and 198 healthy blood donors were recruited from the First Affiliated Hospital of Xiamen University. Outcome measures: Genotyping was performed by molecular beacon real-time PCR and Sanger sequencing. Results: None of our participants carried the rs75932628-T mutation. Conclusions: Our results corroborate and extend previous findings, concluding that the variant rs75932628-T (p.R47H) in TREM2 is not a risk factor for LA or PD in the Han Chinese population.