Association between APOE polymorphism and metabolic syndrome in Uyghur ethnic men. Issue 1 (6th January 2016)

• Record Type: Journal Article
• Authors: Sun, YuPing; Wei, Rong; Yan, DanDan; Xu, FeiLi; Zhang, XiaoJin; Zhang, Bei; Yimiti, Delixiati; LI, Hui; Sun, HongYan; Hu, Cheng; Luo, Li; Yao, Hua
• Is Part Of: BMJ open. Volume 6:Issue 1(2016)
• Publication Date: 2016-01-06
• Subjects: APOE -- Metabolic Syndrome -- Gene polymorphism -- Uygur ethnic; Medicine -- Research -- Periodicals; 610.72
• DOI: 10.1136/bmjopen-2015-010049
• Languages: English
• ISSNs: 2044-6055

Abstract

Abstract : Objectives: This study aimed to examine the association between apolipoprotein E ( APOE ) polymorphism and metabolic syndrome (MetS) among Uyghur ethnic men in Xinjiang, China. Participants: A total of 482 patients with MetS and 510 healthy sex-matched and age-matched controls were recruited from the Xinjiang Uyghur Autonomous Region of China. The participants were subjected to routine physical and blood biochemical tests, and APOE genotyping was performed. Results: The APOE ε3/3 was the predominant type, with a frequency of 71.8%, while ε2/2 was less common than ε4/4 in Uyghur males. The frequencies of the APOE2, E3 and E4 alleles in Uyghur males were 8.5%, 80.0% and 11.5%, respectively. However, the distribution of APOE genotypes was significantly different between the MetS and control groups (p<0.001). In the MetS group, the frequencies of the ε 2 and ε 4 alleles and the frequencies of the ε2/2, ε2/3 and ε2/4 genotypes were significantly lower than those of the control group. Those individuals without the ε 2 and ε 4 alleles had higher MetS prevalence than the other gene carriers, and the ORs of these individuals developing MetS were 1.5 and 1.27 compared to the gene carriers. Triglyceride, serum total cholesterol and low-density lipoprotein cholesterol levels were lower and serum high-density lipoprotein was higher in the ε 2 carriers than the ε 3 carriers, and the prevalence of MetS, central obesity, high blood pressure, hypercholesterolaemia and hypertriglyceridaemia was lower in the APOE 2 group than in the APOE 4 group. The risks of these individuals with ε 4 allele carriers getting these changes were 1.327, 1.780, 1.888, 1.428 and 2.571 times greater than those of ε2 allele carriers. Conclusions: APOE 4 is associated with many individual components of MetS, whereas APOE 2 was associated with a reduced risk of MetS at the univariate level in Uyghur ethnic men.