Peptide sharing between Bordetella pertussis proteome and human sudden death proteins: a hypothesis for a causal link. (August 2013)

• Record Type: Journal Article
• Authors: Capone, Giovanni; Kanduc, Darja
• Is Part Of: Future microbiology. Volume 8:Number 8(2013:Aug.)
• Page Start: 1039
• Page End: 1048
• Publication Date: 2013-08
• Subjects: B. pertussis infection -- pentapeptide sharing -- potential crossreactivity -- sudden death antigens; Microbiology -- Research -- Periodicals; 616.9041
• DOI: 10.2217/fmb.13.72
• Languages: English
• ISSNs: 1746-0913

Abstract

Aim: To explore the molecular basis of the relationship between Bordetella pertussis infection and sudden death.Methods: B. pertussis proteins were analyzed for amino acid sequence identity to a set of 67 human proteins that, when altered, have been associated with sudden death.Results: More than 82, 000 pentapeptides are shared between B. pertussis proteins and sudden death-associated antigens.Conclusion: Results suggest that a possible link between B. pertussis infection and sudden death might be represented by potential immunological cross-reactions occurring between B. pertussis proteins and human proteins associated to sudden death.