Prognostic Impact of Pretreatment Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography SUVmax in Patients With Locally Advanced Cervical Cancer. Issue 3 (1st March 2018)

• Record Type: Journal Article
• Authors: Cima, Simona; Perrone, Anna Myriam; Castellucci, Paolo; Macchia, Gabriella; Buwenge, Milly; Cammelli, Silvia; Cilla, Savino; Ferioli, Martina; Ferrandina, Gabriella; Galuppi, Andrea; Salizzoni, Eugenio; Rubino, Daniela; Fanti, Stefano; De Iaco, Pierandrea; Morganti, Alessio Giuseppe
• Is Part Of: International journal of gynecological cancer. Volume 28:Issue 3(2018)
• Page Start: 575
• Page End: 580
• Publication Date: 2018-03-01
• Subjects: Cervix cancer -- 18F-FDG-PET/CT -- Radiotherapy -- Chemotherapy -- Prognostic factor; Generative organs, Female -- Cancer -- Periodicals; 616.99465
• DOI: 10.1097/IGC.0000000000001207
• Languages: English
• ISSNs: 1048-891X

Abstract

Abstract : Objective: The aim of this study was to investigate the impact of SUVmax fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) measured in the primary tumor, pelvic and para-aortic node with disease-free survival (DFS) and overall survival (OS) in patients with locally advanced cervical cancer. Methods and Materials: A total of 92 patients with histological diagnosis of locally advanced cervical cancer are treated with radiochemotherapy plus brachytherapy boost from January 2008 to April 2014 in our Institution. A pretreatment FDG-PET/CT for staging and radiotherapy planning was performed, and the value of SUVmax measured in primary tumor and positive nodes was related to DFS and OS. Results: Univariate analysis showed that DFS is related to FDG-PET/CT positive para-aortic nodes ( P = 0.01), International Federation of Gynecology and Obstetrics (FIGO) stage of disease ( P = 0.01), and primary tumor SUVmax ( P = 0.02), and OS is related to positive para-aortic nodes ( P = 0.01) and primary tumor SUVmax ( P = 0.02). In multivariate analysis, DFS is modified by FDG-PET/CT positive para-aortic lymph nodes, stage and high T SUVmax ( P = 0.02; P = 0.003; P = 0.04), but the only worse prognostic factor of OS is the high SUVmax in the primary tumor ( P = 0.01). Conclusions: We found that T SUVmax, stage, and para-aortic lymph node status assessed by FDG-PET were independent prognostic factors of DFS, whereas only T SUVmax correlated with OS.