A genetic advance: lipoprotein(a) in aortic stenosis. (June 2013)

• Record Type: Journal Article
• Authors: Yanagawa, Bobby; Gupta, Nandini; Verma, Subodh
• Is Part Of: Clinical lipidology. Volume 8:Number 3(2013)
• Page Start: 307
• Page End: 309
• Publication Date: 2013-06
• Subjects: aortic stenosis -- genetics -- genome-wide association study -- Lp(a) -- pathogenesis; Lipids -- Periodicals; 616.3997
• DOI: 10.2217/clp.13.25
• Languages: English
• ISSNs: 1758-4299

Abstract

Evaluation of: Thanassoulis G, Campbell CY, Owens DS et al. Genetic associations with valvular calcification and aortic stenosis. N. Engl. J. Med. 368, 503–512 (2013) . Thanassoulis et al. performed a genome-wide association study of 6924 patients to demonstrate an association between genetic variants in the gene encoding lipoprotein(a) (Lp(a)) and aortic valve calcification, as well as clinical aortic stenosis, a disease for which the only treatment is surgical or catheter-based valve replacement. Given the ethnic variability in Lp(a) expression, the authors confirmed the association between Lp(a) and aortic valve calcification in European, African–American and Hispanic–American cohorts. This finding reveals a potential candidate for targeted treatment of aortic stenosis, as well as providing an important insight into the potential role of Lp(a) in cholesterol transport and fibrinolysis in its pathogenesis.