Low-dose computed tomography screening for lung cancer: results of the first screening round. (September 2013)

• Record Type: Journal Article
• Authors: Horeweg, Nanda; Nackaerts, Kristiaan; Oudkerk, Matthijs; de Koning, Harry J
• Is Part Of: Journal of comparative effectiveness research. Volume 2:Number 5(2013)
• Page Start: 433
• Page End: 436
• Publication Date: 2013-09
• Subjects: early detection of cancer -- histology -- lung neoplasms -- neoplasm staging -- predictive value of tests -- tomography -- x-ray computed tomography; Medical care -- Research -- Periodicals; Medical care -- Research -- Evaluation -- Periodicals; Medical care -- Decision making -- Periodicals; Evidence-based medicine -- Periodicals; Medicine, Comparative -- Periodicals; 362.1072
• DOI: 10.2217/cer.13.57
• Languages: English
• ISSNs: 2042-6305

Abstract

Evaluation of: National Lung Screening Trial Research Team, Church TR, Black WC, Aberle DR et al. Results of initial low-dose computed tomographic screening for lung cancer. N. Engl. J. Med. 368, 1980–1991 (2013). In 2011, the US NLST trial demonstrated that mortality from lung cancer can be reduced by using low-dose computed tomography (LDCT) screening rather than chest x-ray (CXR) screening. This paper from the US NLST research team focuses on the results of the initial round of LDCT for lung cancer. A total of 53, 439 participants were included and randomly assigned to LDCT screening (n = 26, 715) or CXR screening (n = 26, 724). In total, 27.3% of the participants in the LDCT group and 9.2% in the CXR group had a positive screening result. As a result, 3.8% (LDCT group) and 5.7% (CXR group) of these subjects were diagnosed with lung cancer. The sensitivity (93.8%) and specificity (73.4%) for lung cancer were higher for LDCT compared with CXR screening; 73.5 and 91.3%, respectively.