A longitudinal study of lung function from 1 month to 18 years of age. Issue 11 (2nd June 2014)

• Record Type: Journal Article
• Authors: Turner, Steve; Fielding, Shona; Mullane, Dave; Cox, Des W; Goldblatt, Jack; Landau, Lou; le Souef, Peter
• Is Part Of: Thorax. Volume 69:Issue 11(2014)
• Page Start: 1015
• Page End: 1020
• Publication Date: 2014-06-02
• Subjects: Asthma Mechanisms -- Paediatric asthma; Chest -- Diseases -- Periodicals; Thorax; Chest -- Diseases; Periodicals; Periodicals; 617.54
• DOI: 10.1136/thoraxjnl-2013-204931
• Languages: English
• ISSNs: 0040-6376

Abstract

Abstract : Background: Our hypothesis was that factors associated with wheeze will be associated with changes in lung function trajectory between 1 month and 18 years of age. Methods: Measurements of lung function were made in individuals aged 1, 6 and 12 months (V'maxFRC), and also at ages 6, 12 and 18 years (FEF25–75 ). Changes in lung function over time relative to sex, a history of asthma, maternal asthma and other factors were explored using random coefficient models. Results: Lung function (maximal flow at functional residual capacity in infants and FEF25–75 in children) was determined in 241 individuals at 1 month, 192 at 6 months, 164 at 12 months, 106 at 6 years, 183 at 12 years and 141 at 18 years. In the multivariable model, maternal asthma (mean reduction in lung function 9.8%), flow limitation (mean reduction 17.4%), infant atopy (mean reduction 12.6%) and maternal smoking (mean reduction in lung function 8.1%) were acting independently. When interactions with time were sought, the reduction in lung function associated with maternal asthma and infant atopy were consistent over time, but % lung function increased in boys by a mean of 1%/year compared with girls, in flow-limited individuals by 3.0%/year and by 0.9%/year for those exposed to maternal smoking during pregnancy compared to other cohort members. Conclusions: Decrements in lung function in 18-year-olds associated with maternal asthma and early onset atopy may be determined by 1 month of age. Low initial lung function in some individuals can 'recover' in some settings.