Incidence of Lymph Node Metastases in Women With Low-Risk Early Cervical Cancer (<2 cm) Without Lymph-Vascular Invasion. Issue 4 (1st May 2018)

• Record Type: Journal Article
• Authors: Minig, Lucas; Fagotti, Anna; Scambia, Giovanni; Salvo, Gloria; Patrono, María Guadalupe; Haidopoulos, Dimitrios; Zapardiel, Ignacio; Domingo, Santiago; Sotiropoulou, Maria; Chisholm, Gary; Ramirez, Pedro T.
• Is Part Of: International journal of gynecological cancer. Volume 28:Issue 4(2018)
• Page Start: 788
• Page End: 793
• Publication Date: 2018-05-01
• Subjects: Cervical cancer -- Early stage -- Lymph node metastasis -- Lymph-vascular space invasion; Generative organs, Female -- Cancer -- Periodicals; 616.99465
• DOI: 10.1097/IGC.0000000000001236
• Languages: English
• ISSNs: 1048-891X

Abstract

Abstract : Objective: To determine the incidence of lymph node metastasis in women with low-risk cervical cancer stage IA2 or IB1 (&lt;2 cm) without lymph-vascular space invasion. Methods: A multicenter retrospective study was performed in patients who underwent radical or simple hysterectomy, conization, or trachelectomy plus pelvic lymphadenectomy for cervical cancer between January 2000 and June 2016. Results: A total of 271 patients were included in the study. Median age and body mass index were 46 years (range, 23–77 years) and 24 kg/m 2 (range, 18–48 kg/m 2 ), respectively. Twenty-two patients had stage IA2 (8.1%), and 249 (91.9%) had stage IB1. The median tumor size was 14 mm (range, 5–20 mm). Tumor grades were 1 (n = 63 [23.2%]), 2 (n = 120 [44.3%]), 3 (n = 63 [23.2%]), and unknown (25 [9.2%]). Median depth stromal invasion was 6 mm (range, 3–20 mm). Histologic subtypes included squamous (n = 171 [63.1%]), adenocarcinoma (n = 92 [33.9%]), and adenosquamous (n = 8 [3.0%]). Overall incidence of lymph node metastasis was 2.9% (n = 8). The incidence of lymph node involvement in G1, G2, and G3 was 0% (0/63), 5% (6/120), and 3.1% (2/63), respectively. No patient with stage IA2 (regardless of grade or histology) or G1 cervical cancer less than 2 cm (stage IB1) had lymph node metastasis. Conclusions: Patients with stage IA2 or IB1 (G1) with tumor size of less than 2 cm and no lymph-vascular space invasion may not need lymph node evaluation. On the other hand, 95% and 98% of patients with grade 2 or 3 tumors, respectively, could potentially undergo an unnecessary lymphadenectomy. Further studies with bigger sample size are required to confirm these results.