Impact of expression of the uPA system in sarcomas. (June 2013)

• Record Type: Journal Article
• Authors: Taubert, Helge; Magdolen, Viktor; Kotzsch, Matthias
• Is Part Of: Biomarkers in medicine. Volume 7:Number 3(2013)
• Page Start: 473
• Page End: 480
• Publication Date: 2013-06
• Subjects: PAI-1 -- soft tissue and bone sarcoma -- uPA -- uPA receptor; Biochemical markers -- Periodicals; 610.28
• DOI: 10.2217/bmm.12.105
• Languages: English
• ISSNs: 1752-0363

Abstract

The uPA system mainly comprises the urokinase-type plasminogen activator uPA, the cell-surface receptor uPA receptor and the inhibitor PAI-1. Its clinical and prognostic impact especially in breast cancer is well investigated. In this short report, we summarize the published data describing expression of uPA, PAI-1 and uPA receptor and their relevance to clinical and survival data in sarcomas underlining their impact as tumor biomarkers in this tumor type as well.