High peripheral levels of h-FABP are associated with poor prognosis in end-stage heart failure patients with mechanical circulatory support. (June 2013)

• Record Type: Journal Article
• Authors: Cabiati, Manuela; Caselli, Chiara; Caruso, Raffaele; Prescimone, Tommaso; Verde, Alessandro; Botta, Luca; Parodi, Oberdan; Ry, Silvia Del; Giannessi, Daniela
• Is Part Of: Biomarkers in medicine. Volume 7:Number 3(2013)
• Page Start: 481
• Page End: 492
• Publication Date: 2013-06
• Subjects: cardiac injury -- heart failure -- h-FABP -- left ventricular assist device -- NT-proBNP; Biochemical markers -- Periodicals; 610.28
• DOI: 10.2217/bmm.13.6
• Languages: English
• ISSNs: 1752-0363

Abstract

Aim: To associate the time-course of h-FABP and N-terminal pro B-type natriuretic peptide (NT-proBNP)after left ventricular assist device (LVAD) implantation to outcome in end-stage heart failure patients.Materials & methods: Patients (n = 14, NYHA class III/IV; left ventricular ejection fraction <25% were enrolled; ten survived up to 1 month after LVAD (survivors) and four died of multiorgan failure within 2 weeks (nonsurvivors). Blood samples were obtained at admission; at 4, 24 and 72 h; and at 1 and 4 weeks after LVAD.Results: h-FABP significantly increases after surgery, decreasing since 72 h in all patients. At 72 h all survivor patients present h-FABP lower than the median value. N-terminal pro B-type natriuretic peptide is not associated with patient outcome at any time.Conclusion: High h-FABP levels, indicating the presence of more severe myocardial damage, are associated with a poor prognosis in patients with LVAD, suggesting that an early cardiac injury marker could improve the prediction of clinical outcome.