European Bioanalysis Forum: recommendation for dealing with internal standard variability. (October 2014)

• Record Type: Journal Article
• Authors: White, Stephen; Adcock, Neil; Elbast, Walid; Hiller, Jim; Knutsson, Magnus; Lausecker, Berthold; Long, Jeff; McDougall, Stuart; Salavert, Fabrice; Sangster, Timothy; Verhaeghe, Tom; Amsterdam, Peter van
• Is Part Of: Bioanalysis. Volume 6:Number 20(2014)
• Page Start: 2767
• Page End: 2774
• Publication Date: 2014-10
• Subjects: Drugs -- Analysis -- Periodicals; 615.19005
• DOI: 10.4155/bio.14.221
• Languages: English
• ISSNs: 1757-6180

Abstract

Adequate monitoring of internal standard (IS) response across an analytical run and identification of anomalies is now a common expectation. However, the means to conduct this assessment in an appropriate manner is unclear and differs widely between laboratories. A European Bioanalysis Forum (EBF) topic team was formed to survey current practices within European Bioanalysis Forum member companies and to recommend a best practice approach for dealing with IS response variability.