Menstrual cycle resumption and female fertility after autologous hematopoietic stem cell transplantation for multiple sclerosis. (November 2021)

• Record Type: Journal Article
• Authors: Massarotti, Claudia; Sbragia, Elvira; Boffa, Giacomo; Vercelli, Caterina; Zimatore, Giovanni Bosco; Cottone, Salvatore; Frau, Jessica; Raiola, Annamaria; Varaldo, Riccardo; Mancardi, Gianluigi; Inglese, Matilde; Anserini, Paola
• Is Part Of: Multiple sclerosis. Volume 27:Number 13(2021)
• Page Start: 2103
• Page End: 2107
• Publication Date: 2021-11
• Subjects: Aggressive multiple sclerosis -- amenorrhea -- autologous hematopoietic stem cell transplantation -- fertility -- menstrual cycle; Central nervous system -- Diseases -- Periodicals; Myelin sheath -- Diseases -- Periodicals; Inflammation -- Periodicals; Multiple sclerosis -- Periodicals; Central Nervous System Diseases -- Periodicals; Demyelinating Diseases -- Periodicals; Inflammation -- Periodicals; Multiple Sclerosis -- Periodicals; Système nerveux central -- Maladies -- Périodiques; Gaine de myéline -- Maladies -- Périodiques; Inflammation (Pathologie) -- Périodiques; Sclérose en plaques -- Périodiques; Electronic journals; 616.834005
• DOI: 10.1177/13524585211000616
• Languages: English
• ISSNs: 1352-4585

Abstract

Data on fertility after autologous hematopoietic stem cell transplantation (aHSCT) in women with multiple sclerosis (MS) are inconclusive. This study aims to report on post-aHSCT menstrual resumption in a multi-center MS-women cohort. Out of 43 women, 30 (70%) recovered menses after a mean time of 6.8 months. Older age (odds ratio (OR) = 0.5, p < 0.0001) and previous pulsed cyclophosphamide (OR = 0.44, p = 0.005) were independently associated with a reduced menstrual recovery probability. Conditioning regimens' intensity resulted not associated with post-procedure amenorrhea. Our results highlight younger age as significantly associated with menses recovery; proper fertility counseling for MS women candidated to aHSCT both prior- and post-transplantation is therefore warranted.