Dysregulation of lncRNA in Helicobacter pylori-Infected Gastric Cancer Cells. (10th July 2021)

• Record Type: Journal Article
• Authors: Yousefi, Leila; Osquee, Hamid Owaysee; Ghotaslou, Reza; Rezaee, Mohammad Ahangarzadeh; Pirzadeh, Tahereh; Sadeghi, Javid; Hemmati, Fatemeh; Yousefi, Bahman; Moaddab, Seyyed Yaghoub; Yousefi, Mehdi; Shirmohammadi, Masoud; Somi, Mohammad Hossein; Ganbarov, Khudaverdi; Kafil, Hossein Samadi
• Other Names: Ergün Sercan Academic Editor.
• Is Part Of: BioMed research international. Volume 2021(2021)
• Publication Date: 2021-07-10
• Subjects: Medicine -- Periodicals; Biology -- Periodicals; Biotechnology -- Periodicals; Life sciences -- Periodicals; 610.5
• DOI: 10.1155/2021/6911734
• Languages: English
• ISSNs: 2314-6133

Abstract

Abstract : Helicobacter pylori ( H. pylori ) infection is the most common cause of gastric cancer (GC). This microorganism is genetically diverse; GC is caused by several genetic deregulations in addition to environmental factors and bacterial virulence factors. lncRNAs (long noncoding RNAs) are significant biological macromolecules in GC, have specific functions in diseases, and could be therapeutic targets. Altered lncRNAs can lead to the abnormal expression of adjacent protein-coding genes, which may be important in cancer development. Their mechanisms have not been well understood, so we are going to investigate the risk of GC in a population with both high lncRNA and H. pylori infection.