PPARγ Plays an Important Role in Acute Hepatic Ischemia-Reperfusion Injury via AMPK/mTOR Pathway. (5th July 2021)

• Record Type: Journal Article
• Authors: Wu, Liwei; Yu, Qiang; Cheng, Ping; Guo, Chuanyong
• Other Names: Lau Christopher Academic Editor.
• Is Part Of: PPAR research. Volume 2021(2021)
• Publication Date: 2021-07-05
• Subjects: Peroxisomes -- Periodicals; Peroxisomal disorders -- Periodicals; 571.65505
• DOI: 10.1155/2021/6626295
• Languages: English
• ISSNs: 1687-4757

Abstract

Abstract : Background . Hepatic ischemia-reperfusion (IR) injury is one of the severe complications associated with liver surgery and leads to liver dysfunction. PPAR γ is always linked with various physiologic pathways, and it can alleviate liver damage in IR injury. Aim . In this study, we explored the potential mechanism of PPAR γ in the pathogenesis of hepatic IR injury by mice model. Methods . After treated with si-PPAR γ or rosiglitazone, mice were subjected to hepatic ischemia-reperfusion. Liver tissue and blood samples were collected to evaluate liver injury and detected relative mRNA and protein expressions. Results . The expression of PPAR γ was increased after reperfusion. And the alleviation of PPAR γ aggravated the liver damage in IR; at the same time, upregulation of the expression of PPAR γ released the liver damage. And these effects of PPAR γ in IR were related to the AMPK/mTOR/autophagy signaling pathway. Conclusion . PPAR γ plays an important role in hepatic IR injury at least partly via the AMPK/mTOR/autophagy pathway.