Leptin concentrations in endometriosis: A systematic review and meta-analysis. (August 2021)
- Record Type:
- Journal Article
- Title:
- Leptin concentrations in endometriosis: A systematic review and meta-analysis. (August 2021)
- Main Title:
- Leptin concentrations in endometriosis: A systematic review and meta-analysis
- Authors:
- Kalaitzopoulos, Dimitrios Rafail
Lempesis, Ioannis G.
Samartzis, Nicolas
Kolovos, Georgios
Dedes, Ioannis
Daniilidis, Angelos
Nirgianakis, Konstantinos
Leeners, Brigitte
Goulis, Dimitrios G.
Samartzis, Eleftherios Pierre - Abstract:
- Highlights: Increased leptin concentrations in both peritoneal fluid and follicular fluid of women with endometriosis. Similar leptin concentrations in both serum or plasma of women with endometriosis compared with control. Our results support a potential pathophysiologic role for leptin in the local microenvironment while decline its use as a blood diagnostic marker. Abstract: Introduction: Endometriosis is an inflammatory condition, affecting mainly women of reproductive age. Leptin is a regulator of food intake and energy expenditure, posing pleiotropic actions, and regulating immunity and fertility. The aim of this study was to systematically review the literature regarding leptin concentrations in biological fluids and tissues of women with endometriosis, and to investigate and propose a possible role of leptin in the pathophysiology of endometriosis. Materials and methods: A systematic search of the literature was conducted in two electronic databases (MEDLINE, COCHRANE) and grey literature for original research articles on humans, published in any language. Results: Twenty-nine studies with 1291 women with endometriosis and 1664 controls were included in the systematic review. Peritoneal fluid and follicular fluid leptin concentrations were higher in endometriosis compared with control group [mean difference (MD) 7.10, 95 % confidence interval (CI) 4.76 to 9.44 ng/mL, 18 studies), (MD 1.35, 95 % CI 0.54–2.17 ng/ml, 2 studies) respectively. No differences were evidentHighlights: Increased leptin concentrations in both peritoneal fluid and follicular fluid of women with endometriosis. Similar leptin concentrations in both serum or plasma of women with endometriosis compared with control. Our results support a potential pathophysiologic role for leptin in the local microenvironment while decline its use as a blood diagnostic marker. Abstract: Introduction: Endometriosis is an inflammatory condition, affecting mainly women of reproductive age. Leptin is a regulator of food intake and energy expenditure, posing pleiotropic actions, and regulating immunity and fertility. The aim of this study was to systematically review the literature regarding leptin concentrations in biological fluids and tissues of women with endometriosis, and to investigate and propose a possible role of leptin in the pathophysiology of endometriosis. Materials and methods: A systematic search of the literature was conducted in two electronic databases (MEDLINE, COCHRANE) and grey literature for original research articles on humans, published in any language. Results: Twenty-nine studies with 1291 women with endometriosis and 1664 controls were included in the systematic review. Peritoneal fluid and follicular fluid leptin concentrations were higher in endometriosis compared with control group [mean difference (MD) 7.10, 95 % confidence interval (CI) 4.76 to 9.44 ng/mL, 18 studies), (MD 1.35, 95 % CI 0.54–2.17 ng/ml, 2 studies) respectively. No differences were evident in serum (MD 0.92, 95 % CI -0.84 to 2.68 ng/mL, 12 studies) or plasma (MD -0.95, 95 % CI -4.63 to 2.72 ng/mL, 3 studies) between the groups. No meta-analysis was conducted for ovarian tissue leptin (2 studies). Conclusions: This meta-analysis provided evidence for increased leptin concentrations in both peritoneal fluid and follicular fluid of women with endometriosis compared with control; these differences were not present in the serum or plasma. The above results support a potential pathophysiologic role for leptin in the local microenvironment while declines its use as a blood diagnostic marker. Furthermore, we propose a possible role of leptin in the pathophysiology of endometriosis. … (more)
- Is Part Of:
- Journal of reproductive immunology. Volume 146(2021)
- Journal:
- Journal of reproductive immunology
- Issue:
- Volume 146(2021)
- Issue Display:
- Volume 146, Issue 2021 (2021)
- Year:
- 2021
- Volume:
- 146
- Issue:
- 2021
- Issue Sort Value:
- 2021-0146-2021-0000
- Page Start:
- Page End:
- Publication Date:
- 2021-08
- Subjects:
- Endometriosis -- Endometrioma -- Leptin -- Adiponectin -- Leptin-binding protein -- Leptin receptor -- Peritoneal fluid -- Serum -- Plasma -- Follicular fluid
Reproduction -- Immunological aspects -- Periodicals
Immunology -- Periodicals
Allergy and Immunology -- Periodicals
Reproduction -- Periodicals
Reproduction -- Immunologie -- Périodiques
Immunologie -- Périodiques
Immunology
Reproduction -- Immunological aspects
Periodicals
Electronic journals
Electronic journals
615.766 - Journal URLs:
- http://www.sciencedirect.com/science/journal/01650378 ↗
http://www.elsevier.com/journals ↗ - DOI:
- 10.1016/j.jri.2021.103338 ↗
- Languages:
- English
- ISSNs:
- 0165-0378
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 5049.670000
British Library DSC - BLDSS-3PM
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