Variability in Postheparin Hepatic Lipase Activity Is Associated with Plasma Adiponectin Levels in African Americans. Issue 4 (1st May 2007)

• Record Type: Journal Article
• Authors: Clarenbach, Jacob J.; Vega, Gloria Lena; Adams-Huet, Beverley; Considine, Robert V.; Ricks, Madia; Sumner, Anne E.
• Is Part Of: Journal of investigative medicine. Volume 55:Issue 4(2007)
• Page Start: 187
• Page End: 194
• Publication Date: 2007-05-01
• Subjects: adiponectin -- African Americans -- hepatic triglyceride lipase; Clinical medicine -- Periodicals; Medicine -- Research -- Periodicals; Medicine; Research -- United States; Clinical medicine; Medicine -- Research; Periodicals; 616.075
• DOI: 10.2310/6650.2007.07001
• Languages: English
• ISSNs: 1081-5589

Abstract

Abstract : Background: African Americans commonly have normal high-density lipoprotein cholesterol (HDL-C) and low triglyceride levels despite having insulin resistance and obesity. The higher than expected HDL-C levels are usually attributed to low levels of hepatic triglyceride lipase (HTGL) activity. Factors that regulate HTGL in African Americans are not well delineated. Methods: In the current study, HTGL activity was examined in relation to indices of body fat (body mass index [BMI] and waist circumference [WC]), insulin resistance (fasting plasma insulin and homeostasis model assessment of insulin resistance [HOMA-IR] index), and adipokines (adiponectin and leptin). Sixty-three African Americans (33 men, 30 women; median age 31 years, range 20-50 years; median BMI 28.6 kg/m 2, range 19.7-54.7 kg/m 2 ) had anthropometry and measurement of postheparin lipase activities (HTGL), plasma HDL-C, triglycerides, and plasma adiponectin. Results: HTGL correlated strongly with HDL-C ( r = −.52, p < .0001) and adiponectin ( r = −.49, p < .001). HTGL increased with BMI and WC ( r = .297, p = .018 and r = .301, p = .016, respectively). Adiponectin correlated strongly with HDL-C ( r = .50, p < .0001) and triglycerides ( r = −.493, p < .001). From multiple regression models, 28% of HTGL variability among African Americans can be explained by adiponectin levels in combination with gender and 35% of HTGL is explained with HDL-C included in the model. Conclusion: The data suggest that adiponectin is a significant metabolic concomitant of HTGL activity in African Americans.