105 EFFICIENCY OF TREATMENT OF OSTEOPOROSIS IN DIFFERENT ETHNIC GROUPS ASSESSED BY DUAL-ENERGY X-RAY ABSORPTIOMETRY. Issue 1 (1st January 2007)

• Record Type: Journal Article
• Authors: Jayawardena, S.; Sethi, A.; Volozhanina, E.; Dungao, J.; Niranjan, S.
• Is Part Of: Journal of investigative medicine. Volume 55:Issue 1(2007)
• Page Start: S263
• Page End: S264
• Publication Date: 2007-01-01
• Subjects: Clinical medicine -- Periodicals; Medicine -- Research -- Periodicals; Medicine; Research -- United States; Clinical medicine; Medicine -- Research; Periodicals; 616.075
• Languages: English
• ISSNs: 1081-5589

Abstract

Abstract : Background: Osteoporosis in women, especially after menopause, is associated with a high risk of fracture even with minimally traumatic events. The lifetime risk of osteoporotic fracture is as high as 50% in white and Asian women. Objective: Compare the efficacy of standard treatment for osteoporosis among females from different ethnic groups. Method: Retrospective study done in outpatient clinic follow-up in a community-based hospital, which caters to a multiethnic community in Brooklyn. Caucasian, African American, Hispanic, and Asian females between the ages of 60 and 80 years who had a dual-energy x-ray absorptiometry (DXA) scan and had a diagnosis of osteoporosis (T < −2.5) were started on calcium, vitamin D, and risedronate. A repeat DXA was done as follow-up in 2 years to see the response to treatment and was compared between the ethnic groups. Results: A total of 195 patients were included in the study: 50 Caucasians, 45 African Americans, 53 Hispanics, and 47 Asians. The average age was 68.3 years. T scores of the spines were compared in DXA scans done 2 years apart. On the first DXA scan, the Caucasian group had an average T score of −2.8; in Asians, it was −3.0; in the Hispanic group, it was −2.8; and for the African American group of patients, it was −2.6. Two years later, the DXA scan done showed an average T score of −0.8 for the Caucasians, −1.0 for the Asians, −1.0 for Hispanics, and −0.7 for the African Americans. All ethnic groups responded well to treatment; the responses by Caucasians and Asians were better than those of the Hispanics and African Americans but not statistically significant ( p < .05). Conclusion: Patients with osteoporosis definitely need treatment to reduce the incidence of fracture. In our study, all ethnic groups showed equally remarkable improvement in their bone density with standard osteoporosis treatment.