Front Cover: Elucidating the Roles of Fenton Reactants in Drug‐Treated Cells by Using a Selective Rhodamine‐Thiophenol Fluorogenic Sensor (2/2021). Issue 2 (9th April 2021)

• Record Type: Journal Article
• Authors: Wang, Zhanlong; Hao Yeo, Jia; New, Elizabeth J.
• Is Part Of: Analysis & Sensing. Volume 1:Issue 2(2021)
• Page Start: 70
• Page End: 70
• Publication Date: 2021-04-09
• Subjects: cisplatin -- Fenton reaction -- ferroptosis -- fluorescent sensors -- rhodamine; Chemistry, Analytic -- Periodicals; Analytical biochemistry -- Periodicals; 543
• DOI: 10.1002/anse.202100009
• Languages: English
• ISSNs: 2629-2742

Abstract

Abstract : The Front Cover shows the structure of RTFt1, a rhodamine‐based sensor that can report on the presence of the Fenton reactants, Fe(II) and H2 O2 . Two sets of cells are depicted: the healthy cells have low levels of Fenton reactants, so the sensor remains in its non‐fluorescent form; while cells undergoing ferroptosis on the right have higher Fenton activity, so the sensor is converted to its red‐fluorescent form, visible by confocal microscopy. More information can be found in the Communication by E. J. New and co‐workers .