Metal‐Free Direct Oxidative C−N Bond Coupling of Quinoxalin‐2(1H)‐ones with Azoles under Mild Conditions. Issue 15 (21st April 2021)

• Record Type: Journal Article
• Authors: Guo, Jingwen; Zhang, Lina; Du, Xinyue; Zhang, Liting; Cai, Yuepiao; Xia, Qinqin
• Is Part Of: European journal of organic chemistry. Issue 15(2021)
• Page Start: 2230
• Page End: 2238
• Publication Date: 2021-04-21
• Subjects: Azoles -- [Bis(trifluoroacetoxy)iodo]benzene -- C−N coupling -- Quinoxalin-2(1H)-ones -- Radicals; Chemistry, Organic -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1002/ejoc.202100269
• Languages: English
• ISSNs: 1434-193X

Abstract

Abstract: Direct C3−H amination of quinoxalin‐2(1 H )‐ones with azoles under mild conditions promoted by PIFA has been achieved in good yield in a very fast manner. Mechanistic study revealed that the reaction proceeds through a radical process. In addition, this method could be applied to gram‐scale reaction. Abstract : Direct C3−H amination of quinoxalin‐2(1 H )‐ones with azoles has been achieved in a very fast manner. This protocol features broad substrate scope, good yields, and mild reaction conditions.