Early stopping in clinical PET studies: How to reduce expense and exposure. Issue 11 (November 2021)

• Record Type: Journal Article
• Authors: Svensson, Jonas E; Schain, Martin; Knudsen, Gitte M; Ogden, R Todd; Plavén-Sigray, Pontus
• Is Part Of: Journal of cerebral blood flow & metabolism. Volume 41:Issue 11(2021)
• Page Start: 2805
• Page End: 2819
• Publication Date: 2021-11
• Subjects: Early stopping -- sequential testing -- Bayes factor -- positron emission tomography -- tutorial; Cerebral circulation -- Periodicals; Brain -- Metabolism -- Periodicals; Brain -- Blood-vessels -- Periodicals; Cerebrovascular disease -- Periodicals; 612.824
• DOI: 10.1177/0271678X211017796
• Languages: English
• ISSNs: 0271-678X

Abstract

Clinical positron emission tomography (PET) research is costly and entails exposing participants to radioactivity. Researchers should therefore aim to include just the number of subjects needed to fulfill the purpose of the study. In this tutorial we show how to apply sequential Bayes Factor testing in order to stop the recruitment of subjects in a clinical PET study as soon as enough data have been collected to make a conclusion. By using simulations, we demonstrate that it is possible to stop a study early, while keeping the number of erroneous conclusions low. We then apply sequential Bayes Factor testing to a real PET data set and show that it is possible to obtain support in favor of an effect while simultaneously reducing the sample size with 30%. Using this procedure allows researchers to reduce expense and radioactivity exposure for a range of effect sizes relevant for PET research.