Sexually transmitted infections in young people and factors associated with HIV coinfection: an observational study in a large city. Issue 5 (5th May 2019)

• Record Type: Journal Article
• Authors: Sentís, Alexis; Martin-Sanchez, Mario; Arando, Maider; Vall, Martí; Barbera, María Jesus; Ocaña, Inma; González Cordón, Ana; Alsina, Mercè; Martin-Ezquerra, Gemma; Knobel, Hernando; Gurguí, Mercè; Vives, Alvaro; Coll, Josep; Caylà, Joan Artur; Garcia de Olalla, Patricia
• Other Names: author non-byline.; Rius Cristina author non-byline.; Gil Sonia author non-byline.; Gorrindo Pilar author non-byline.; Clos Roser author non-byline.; Sánchez Raquel author non-byline.; Ros Miriam author non-byline.; Masdeu Eva author non-byline.; Simon Pere author non-byline.; Santomà Maria Jose author non-byline.; Armengol Pere author non-byline.; Curran Adrià author non-byline.; Ribera Esteve author non-byline.; Falcó Vicenç author non-byline.; Mateo Maria Gracia author non-byline.; Gutierrez M Mar author non-byline.; Domingo Pere author non-byline.; López-contreras Joaquin author non-byline.; Villar Judit author non-byline.; Guelar Ana author non-byline.; Mothe Beatriz author non-byline.; Fuertes Irene author non-byline.; Cordon Ana Gonzalez author non-byline.; Blanco José L author non-byline.; García Felipe author non-byline.; Mallolas Josep author non-byline.; Miró Josep M author non-byline.; Rius Aspb (cristina author non-byline.; Gil Sonia author non-byline.; Gorrindo Pilar author non-byline.; Clos Roser author non-byline.; Sánchez Raquel author non-byline.; Ros Miriam author non-byline.; Masdeu Eva author non-byline.; Simon Pere author non-byline.; Santomà) Maria Jose author non-byline.; La vall d'hebron (pere armengol Hospital De author non-byline.; Curran Adrià author non-byline.; Ribera Esteve author non-byline.; Falcó) Vicenç author non-byline.; La santa creu i sant pau (maria gracia mateo Hospital De author non-byline.; Gutierrez M Mar author non-byline.; Domingo Pere author non-byline.; López-contreras) Joaquin author non-byline.; Mar (judit villar Hospital Del author non-byline.; Guelar, ) Ana author non-byline.; Tries i pujol (beatriz mothe Hospital Germans author non-byline.; De barcelona (irene fuertes Hospital Clínic author non-byline.; Cordon Ana Gonzalez author non-byline.; Blanco José L author non-byline.; García Felipe author non-byline.; Mallolas Josep author non-byline.; Miró) Josep M author non-byline.;
• Is Part Of: BMJ open. Volume 9:Issue 5(2019)
• Publication Date: 2019-05-05
• Subjects: sexually transmitted infections -- adolescents -- young people -- incidence study -- trends -- Hiv coinfection; Medicine -- Research -- Periodicals; 610.72
• DOI: 10.1136/bmjopen-2018-027245
• Languages: English
• ISSNs: 2044-6055

Abstract

Abstract : Objectives: Young people are a critical target group for sexually transmitted infections (STI) surveillance due to their particular behavioural and social related vulnerability. The aim of this study was to describe the epidemiological characteristics and trends in the incidence of gonorrhoea, syphilis, HIV and venereal lymphogranuloma (LGV) among 15–24-year-olds in Barcelona, and to determine factors associated with HIV coinfection. Design: We performed a population-based incidence study covering the 2007–2015 period. Participants: All new cases of STI—HIV, gonorrhoea, infectious syphilis and LGV—notified to the epidemiological surveillance system in Barcelona between 2007 and 2015. 1218 cases were studied: 84.6% were men, 19.3% were 15–19 years old and 50.6% were born in Spain. Among men, 73.7% were men who have sex with men (MSM); among women, 85.6% were women that have sex with men. Primary and secondary outcomes: Incidence of HIV, gonorrhoea, infectious syphilis and LGV. HIV coinfection. Results: There was an increase in the incidence of gonorrhoea, from 1.9 cases per 10 000 people in 2007 to 7.6/10 000 in 2015 (p<0.01), in MSM from 27.1 to 228.8/10 000 (p<0.01). The incidence of syphilis increased from 0.4/10 000 in 2007 to 3.1/10 000 in 2015 (significant in men only, p<0.01), in MSM from 18.1 to 116.9/10 000 (p<0.01). The incidence of HIV showed a non-significant increase in men (p=0.27), and that of LGV remained stable (p=0.59). Factors associated with increased risk of HIV coinfection included being MSM (adjusted OR[ORa]=14.14, 95% CI 3.34 to 59.91) and having >10 sexual partners (ORa=4.11, 95% CI 1.53 to 11.01) or STI diagnosis during the previous 12 months (ORa=2.06; 95% CI 1.13 to 3.77). Conclusions: The incidence of gonorrhoea and syphilis among 15–24-year-olds increased, while HIV infection remained stable but with a high incidence among MSM. Being MSM, having sex with multiple partners and having a diagnosis of an STI in the previous 12 months were factors associated with HIV coinfection.